How is our body structure stablised? The body is mainly comprised of carbon, hydrogen, oxgen and nitrogen atoms. These atoms interact each other to make our body structure, but how? To answer this quesiton, our group focus on one of biological molecules proteins and particularly on how proteins acquire specific interactions, controle thier dynamics and assemble to make stable protein complex structures.
We study the structure of the centrosome and basal body primarily using structure-biology techniques such as X-ray crystallography and electron microscopy and is particularily interested in the structural integrity and maintenance of centrosomes and cilia. These organelles are essential for normal body development. Mutations in genes related to them result in disease altogether called ciliopathies. Therefore, our research contributes to gain basic biological knowledge as well as medical science.
Please see "Centrosome and cilia" and "Structure biology" for their details!